Reproduction Abstracts

We report the effect of allopregnanolone (ALLO, 3α-hydroxy-5α-pregnan-20-one), on morphological changes and on angiogenesis in the rat ovary. ALLO, one of the best characterized neurosteroids, has effects on the reproductive female biology. First, we previously demonstrated that ALLO inhibited ovulation, secretion of LH and progesterone, increased the prolactin levels, inhibited the female receptivity and apoptosis in rat corpus luteum (CL). Now, we show the effect o...

The evolutionarily conserved Wnt/β-catenin signal transduction pathway controls many biological processes. The objective of this study was to determine the role of this signaling pathway in follicular development and luteal function. To this purpose PMSG–eCG gonadotropin-prepubertal treated female rats were injected with a Wnt inhibitor (XAV939, 5 μg/ovary, Wnt-I group) or vehicle (DMSO, control group) into the bursa of both ovaries the day of hCG administration...